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Génétique et Chemogénomique

Gen&Chem - GrenobleMise à jour le 10/09/2019

Directeur d’équipe

Marie-Odile Fauvarque

Laboratoire de rattachement

Laboratoire de Biologie à Grande Échelle (BGE)

Directeur du laboratoire

Xavier Gidrol


Université Grenoble Alpes - CEA - INSERM

Thèmes principaux

Cancer, Inflammation, Immunité innée, Infectiologie, Signalisation, Ubiquitin, HTS, HCS, Plateforme de criblage

Plateforme de Criblage pour des Molécules BioActives (CMBA)

L'équipe mène une activité de recherche sur les mécanismes de contrôle du cancer, de l'inflammation et de la réponse immunitaire innée ainsi qu'une activité de service, de collaboration et de R&D via la plateforme de Criblage pour des Molécules BioActives (CMBA).

Brevets / Publications / Communications


Maire J., Vincent-Monégat C., Balmand S., Vallier A., Hervé M., Masson F., Parisot N., Vigneron A., Anselme C., Perrin J., Orlans J., Rahioui I., Da Silva P., Fauvarque M.-O., Mengin-Lecreulx D., Zaidman-Rémy A., Heddi A. 2019. Weevil pgrp-lb prevents endosymbiont TCT dissemination and chronic host systemic immune activation. Proc Natl Acad Sci U S A. 19;116(12):5623-5632.



Crespo-Yàñez X., Aguilar-Gurrieri C., Jacomin A.-C., Journet A., Mortier M., Taillebourg E., Soleilhac E., Weissenhorn W., Fauvarque M.-O. 2018. CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis. PLoS Genet. 22;14(6):e1007456.

Courtois G., Fauvarque M.-O. The Many Roles of Ubiquitin in NF-κB Signaling. 2018. Biomedicines. 10;6(2).

Jacomin A.-C., Taillebourg E., Fauvarque M.-O. Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities? 2018. Cells. 19;7(8).



Pandey R.R., Homolka D., Chen K.M., Sachidanandam R., Fauvarque M.-O., Pillai R.S. 2017. Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries. PLoS Genet. 21;13(8):e1006956.



Jacomin A.-C., Fauvarque M.-O., Taillebourg E. 2016. A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila. BMC Cell Biol. 16;17(1):36.

Yang Z., Chen K.M., Pandey R.R., Homolka D., Reuter M., Janeiro B.K., Sachidanandam R., Fauvarque M.-O., McCarthy A.A. and Pillai R.S. 2016. PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway. Mol Cell. 61(1):138-52. 



Do C.V., Faouzi A., Barette C., Farce A., Fauvarque M.-O., Colomb E., Catry L., Berthier-Vergnes O., Haftek M., Barret R., Lomberget T. 2015. Synthesis and biological evaluation of thiophene and benzo[b]thiophene analogs of combretastatin A-4 and isocombretastatin A-4: A comparison between the linkage positions of the 3,4,5-trimethoxystyrene unit. Bioorg Med Chem Lett. 26(1):174-80.

Jacomin A.-C., Bescond A., Soleilhac E., Gallet B., Schoehn G., Fauvarque M.-O. and Taillebourg E. 2015. The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila. PLoS One. 10(11):e0143078.

Homolka D., Pandey R.R., Goriaux C., Brasset E., Vaury C., Sachidanandam R., Fauvarque M.-O. and Pillai R.S. 2015. PIWI Slicing and RNA Elements in Precursors Instruct Directional Primary piRNA Biogenesis. Cell Rep. 12(3):418-28.

Barette C., Soleilhac E., Charavay C., Cochet C. and Fauvarque M.-O. 2015. [Strength and specificity of the CMBA screening platform for bioactive molecules discovery]. Med Sci (Paris). (4):423-31.

Brodin P., DelNery E. and Soleilhac E. 2015. [High content screening in chemical biology: overview and main challenges]. Med Sci (Paris). (2):187-96.

Desroches-Castan A., Quélard D., Demeunynck M., Constant J.F., Dong C, Keramidas M., Coll J.-L., Barette C., Lafanechère L., Feige J.-J. 2015. A new chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras. Oncotarget. 6(7):5382-411.

Martinez A., Soleilhac E., Barette C., Prudent R., Gozzi G.-J., Vassal-Stermann E., Pillet C., Di Pietro A., Fauvarque M.-O., Lafanechere L. 2015. Novel synthetic pharmacophores inducing a stabilization of cellular microtubules. Curr Cancer Drug Targets. 5(1):2-13.



Murie C., Barette C., Lafanechere L. and Nadon R. 2014. Improving Detection of Rare Biological Events in High-Throughput Screens.  Journal of Biomolecular Screening. 20(2):230-41.

Engel E.Viargues P.Mortier M., Taillebourg E., Couté Y., Thevenon D., and Fauvarque M.-O. 2014. Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasome. Cell Commun. Signal. 12(1):41.

Perrin J., Mortier M., Jacomin A.-C., Viargues P., Thevenon D., and Fauvarque M.-O. 2014 The Nonaspanins TM9SF2 and TM9SF4 Regulate the Plasma Membrane Localization and Signalling Activity of the Peptidoglycan Recognition Protein PGRP-LC in Drosophila. J. Innate Immun., 7(1):37-46.

Taillebourg E., Schneider D.S. and Fauvarque M.-O. 2014. The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections. J. Innate Immun. 6(5):632-8.

Fauvarque M.-O. 2014. Small flies to tackle big questions: assaying complex bacterial virulence mechanisms using Drosophila melanogaster. Cell Microbiol. (6):824-33. Review.

Weissenhorn W, Fauvarque MO. 2014. A small switch has a large effect on autophagy. Structure. 22(1):1-2.

Eguether T., Ermolaeva M. A., Zhao Y., Bonnet M. C., Jain A., Pasparakis M., Courtois G., and Tassin A.-M. 2014 The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nat. Commun. 5:4585.



 Murie C., Barette C., Lafanechere L. and Nadon R. 2013. Control-Plate Regression (CPR) Normalization for High-Throughput Screens with Many Active Features.  Journal of Biomolecular Screening; 19(5): 661-671. 

Prudent R.,  Soleilhac E, Barette C, Fauvarque MO et  Lafanechère L. 2013. Les criblages phénotypiques ou comment faire d'une pierre deux coups : Découvrir la cible et la molécule pharmacologique capable de la réguler. Med Sci (Paris); 29: 897-905

 Murie C., Barette C., Lafanechère L. and Nadon R. 2013. Single assay-wide variance experimental (SAVE) design for high-throughput screening. Bioinformatics.  29(23): 3067-3072.

 Boussouar A, Barette C, Nadon R, Saint-Léger A, Broucqsault N, Ottaviani A, Firozhoussen A, Lu Y, Lafanechère L, Gilson E, Magdinier F, Ye J. 2013. Acacetin and chrysin, two polyphenolic compounds, alleviate telomeric position effect in human cells. Mol. Ther. Nucleic Acids. Aug 20;2:e116.

Prudent R., Vassal-Stermann E., Nguyen C.H., Mollaret M., Viallet J., A. Castan, Martinez A., Barette C., Pillet C., Valdameri G. ,  Soleilhac E., A. Di Pietro, J.-J. Feige, M. Billaud, Florent J.-C. and Lafanechère L. 2013. Azaindole derivatives are inhibitors of microtubule dynamics, with anticancer and anti-angiogenic activitiesBritish Journal of Pharmacology; 168(3):673-85.



de Bentzmann S, Giraud C, Bernard CS, Calderon V, Ewald F, Plésiat P, Nguyen C, Grunwald D, Attree I, Jeannot K, Fauvarque MO, Bordi C. 2012. Unique biofilm signature, drug susceptibility and decreased virulence in Drosophila through the Pseudomonas aeruginosa two-component system PprAB. PLoS Pathog; 8(11):e1003052.

Taillebourg E, Gregoire I, Viargues P, Jacomin AC, Thevenon D, Faure M, Fauvarque MO. (2012). The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins. Autophagy, May 1;8(5):767-779

Sampson C.J., Valanne S., Fauvarque M.-O., Hultmark D, Rämet M, Williams MJ. (2012) The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42. Dev Comp Immunol., 38:160-168.

Fais S., Fauvarque M.-O. 2012. TM9 and cannibalism: how to learn more about cancer by studying amoebae and invertebrates. Trends Mol Med., 18:4-5.

Lo E., Soleilhac E., Martinez A., Lafanechère L. and R.  Nadon. 2012. Intensity quantile estimation and mapping – a novel algorithm for the correction of image non-uniformity bias in HCS data. Bioinformatics. 28(20): 2632-2639.

Prudent R., Vassal-Stermann E., Nguyen C.H., Pillet C., Martinez A., Prunier C., Barette C., Soleilhac E., Filhol O., Beghin, A. Valdameri G., Honore S., Aci-Seche S., Grierson D., Antonipillai J., Li R., Di Pietro A., Dumontet C., Braguer D., Florent J.-C., Knapp S., Bernard O. and Lafanechere L. 2012. Pharmacological inhibition of LIM Kinase stabilizes microtubules and inhibits neoplastic growth. Cancer Research. 72(17): 4429-4439.

Camara D., C. Bisanz, C. Barette, J. Van Daele, E. Human, B. Barnard, D. Van Der Straeten, C.P. Stove, W.E. Lambert, R. Douce, E. Maréchal, L.M. Birkholtz, M.F. Cesbron-Delauw, R. Dumas, and F. Rébeillé. 2012. Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by natural product rubreserine.  Journal of Biological Chemistry; 287:22367-22376.



Fauvarque M.-O. and Williams M.J. (2011) Drosophila cellular immunity: a story of migration and adhesion. J Cell Sci., 124:1373-1382

Moucadel, V., R. Prudent, C.F. Sautel, F. Teillet, C. Barette, L. Lafanechere, V. Receveur-Brechot, and C. Cochet. Antitumoral activity of allosteric inhibitors of protein kinase CK2. Oncotarget 2011 2:997-1010.



Soleilhac, E., Nadon, R. and Lafanechere, L. High-content screening for the discovery of pharmacological compounds: Advantages, challenges and potential benefits of recent technological developments. Expert Opin. Drug Discov. 2010 5: 2-10

Lopez-Ramos, M., R. Prudent, V. Moucadel, C.F. Sautel, C. Barette, L. Lafanechere, L. Mouawad, D. Grierson, F. Schmidt, J.C. Florent, P. Filippakopoulos, A.N. Bullock, S. Knapp, J.B. Reiser, and C. Cochet. 2010. New potent dual inhibitors of CK2 and Pim kinases: Discovery and structural insights. FASEB Journal 24:3171-3185.

Prudent, R., V. Moucadel, C.H. Nguyen, C. Barette, F. Schmidt, J.C. Florent, L. Lafanechère, C.F. Sautel, E. Duchemin-Pelletier, E. Spreux, O. Filhol, J.B. Reiser, and C. Cochet. 2010. Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2. Cancer Research; 70:9865-9874.

Gilquin B, Taillebourg E, Cherradi N, Hubstenberger A, Gay O, Merle N, Assard N, Fauvarque MO, Tomohiro S, Kuge O, Baudier J. 2010. The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes. Mol Cell Biol.; (8):1984-1896.