ChemBioScreen
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Lafanechère Laurence

Directrice de RechercheMise à jour le 06/06/2016

equipe

Equipe

Brevets / Publications / Communications


Brevets
•    "Procédé de dépistage et/ou de pronostic d'un cancer par détection d'une protéine du cycle de tyrosination-détyrosination de la tubuline ainsi que ses applications.", 1997,  n° 9709562

•    "Utilisation de cellules appropriées pour le criblage d'inhibiteurs de la tubuline carboxypeptidase et applications de ces derniers comme  anti-cancéreux.", 1997,  n° 9709563

•    "Nouveaux composés pyridocarbazoles et leurs utilisations", Lafanechère L., Nguyen C-H, Vassal E., Barette C, Rivalle C., 20 février 2009,  n° FR 09 00786. Extension internationale: "Pyridocarbazoles type compounds and applications thereof"  Lafanechère L., Nguyen C-H, Vassal E., Barette C, Rivalle C., Prudent R., 19 février 2010, n° Brevet WO 201095042A2

•    "Azaindoles compounds with anticancer and antiangiogneic activities", Lafanechère L, Nguyen C-H, Prudent R., Vassal-Sterman E., Barette C., Viallet J., 27 Août 2012,  n° PCT/IB2012/054385

•    "Composés de type Phényle Propénamide pour leur utilization en tant que médicament", Lafanechère L., Soleilhac E., Martnez A., Barette C., 30 mai 2013, n° FR13 54925

Publications
1.    Vernier P., Fourrier O., Paturle L., Péretti R., Zaim N., Feuerstein C., Gavend M.
Répartition subcellulaire et caractéristiques de fixation des récepteurs dopaminergiques D2 après dénervation nigrostriée.
J. Pharmacol., Paris, 1985, 16, 510.

2.    Paturle L., Fage D., Fourrier O., Vernier P., Feuerstein C., Scatton B.
Cortical ablation fails to influence striatal dopamine target cell supersensitivity induced by nigro-striatal denervation in the rat.
Brain Res., 1987, 402, 383-386.

3.    Paturle L., Fage D., Fourrier O., Vernier P., Feuerstein C., Demenge P., Scatton B.
Failure of cortical ablation to influence the denervation-induced dopamine target cell supersensitivity in the rat striatum.
Biogenic Amines, 1987, 4, 121-127.

4.    Paturle L., Wehland J., Margolis R. L., Job D.
Complete separation of tyrosinated, detyrosinated and non tyrosinatable tubulin using affinity chromatography.
Biochemistry, 1989, 28, 2698-2703.

5.    Paturle-Lafanechère L., Eddé B., Denoulet P., Van Dorsselaer A., Mazarguil H., 
Le Caer J. P., Wehland J. and Job D.
Characterization of a major brain tubulin variant which cannot be tyrosinated.
Biochemistry, 1991, 30, 10523-10528.

6.    Bellocq C., Andrey-Tornare I., Paunier Doret A. M., Maeder B., Paturle L.,
Job D., Haiech J. and Edelstein S.
Purification of assembly-competent tubulin from Saccharomyces cerevisiae.
Eur. J. Biochem., 1992, 210, 343-349.


7.    Paturle-Lafanechère L., Manier M., Trigault N., Pirollet F., Mazarguil H. and Job D.
Accumulation of delta2-tubulin, a major tubulin variant which cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies.
J. Cell Sci., 1994, 107, 1529-1543.

8.    Gagnon C., White J., Cosson J., Huitorel P., Eddé B., Desbruyères E., Paturle-Lafanechère L., Multigner L., Job D. and Cibert C.
The polyglutamylated lateral chain of alpha-tubulin plays a key role in flagellar motility.
J. Cell Sci., 1996, 109,1545-1553.

9.    Lafanechère L., Courtay-Cahen C., Kawakami T., Jacrot M., Rüdiger M., Wehland J., Job D. and Margolis R.L.
Suppression of tubulin tyrosine ligase during tumor growth.
J. Cell Sci., 1998, 111,171-181.

10.    Giraudel A., Lafanechère L., Ronjat M., Garel J.R., Wilson L. and Job D.
Separation of tubulin subunits under non denaturating conditions.
Biochemistry, 1998, 37, 8724-8734.

11.    Guillaud L., Bosc C., Fourest-Lieuvin A., Denarier D., Pirollet F., Lafanechère L. and Job D.
STOP Proteins are responsible for the high degree of microtubule stabilization observed in neuronal cell.
J. Cell Biol., 1998, 142,167-179.

12.    Lafanechère L. and Job D.
The third tubulin pool
Neurochem. Res., 2000, 25, 11-18.

13.    Fleury D., Grenningloh G., Lafanechère L., Antonsson B., Job D. and Cohen-Addad C.
Preliminary crystallographic study of a complex formed between the alpha/beta- tubulin heterodimer and the neuronal growth-associated protein SCG10.
J. Struct. Biol., 2000, 131, 156-158.

14.    Vée S., Lafanechère L., Fisher D., Wehland J., Job D. and Picard A.
Evidence for a role of the alpha-tubulin C-terminus in the regulation of cyclin B synthesis in developing oocytes.
    J. Cell Sci., 2001, 114, 887-898.

15.    Mialhe A., Lafanechère L., Treilleux I., Peloux N., Dumontet C., Brémond A., Panh M.H., Payan R., Wehland J., Margolis R.L. and Job D.  co-premiers auteurs
Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis.
Cancer Res., 2001, 61, 5024-5027.

16.    Sans-Solheillac E., Barette C., Wieczorek S., Roy S., Maréchal E. et
 Lafanechère L.
Criblages phénotypiques et "génétique chimique directe" : une approche innovante pour la découverte de molécules bio-actives et/ou de candidats médicaments.
Spectra Analyse, 2003, 32, 33-37.

17.    Badin-Larcon AC, Boscheron C, Soleilhac JM, Piel M, Mann C, Denarier E, Fourest-Lieuvin A, Lafanechère L, Bornens M, Job D.
Suppression of nuclear oscillations in Saccharomyces cerevisiae expressing Glu tubulin
Proc. Natl. Acad. Sci. U S A. 2004, 101, 5577-5582.

18.    Gache V., Louwagie M., Garin J., Caudron N., Lafanechère L. and Valiron O.
Identification of proteins binding the native tubulin dimer
BBRC. 2005, 327, 35-42.

19.     Seve P., Isaac S., Tredan O., Souquet P.J., Pacheco Y., Perol M., Lafanechère L., Penet A., Peiller E.L., Dumontet C.
Expression of class III beta-tubulin is predictive of patient outcome in patients with non-small cell lung cancer receiving vinorelbine-based chemotherapy.
Clin. Cancer Res., 2005, 11:5481-5486.

20.    Vassal E., Barette C., Fonrose X., Dupont R., Sans-Soleilhac E. and Lafanechère L.
Miniaturization and validation of a sensitive multi-parametric cell-based assay for the concomitant detection of microtubule-destabilizing and microtubule-stabilizing agents.
J. Biomol. Screen., 2006, 11 : 377-389.

21.    Peris L., Andrieux A., Thery  M., Fauré J., Saoudi Y., Lafanechère L., Chilton J., Galjart N., Bornens M., Wordeman L.,  Wehland J. and  Job D.
Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends
J. Cell Biol., 2006,174:839-849.

22.    Khodiyar V.K., Maltais L.J., Sneddon K.M., Smith J.R., Shimoyama M., Cabral F., Dumontet C., Dutcher S.K., Harvey R.J., Lafanechère L., Murray J.M., Nogales E., Piquemal D., Stanchi F., Povey S., Lovering R.C.
A revised nomenclature for the human and rodent alpha−tubulin gene family.
Genomics, 2007, 90:285−289.

23.    Fonrose X., Ausseil F., Soleilhac E., Masson V., David B., Pouny I., Cintrat J-C., Rousseau B., Barette C., Massiot G. and Lafanechère L.
Parthenolide inhibits tubulin carboxypeptidase activity
Cancer Res., 2007, 67:3371−3378.

24.    Lafanechère L.
Chemogenomics and cancer chemotherapy: cell-based assays to screen for small molecules that impair microtubule dynamics.
Comb.Chem. High Throughput Screen., 2008, 11: 617−623.

25.    Prudent R., López−Ramos M., Moucadel V., Barette C., Grierson D., Mouawad L., Florent J−C., Lafanechère L., Schmidt F., Cochet C.
Salicylaldehyde derivatives as new protein kinase CK2 inhibitors
Biochim. Biophys. Acta., 2008,17880:1412−1420.

26.    Prudent R., Moucadel V., Laudet B., Barette C., Lafanechère L., Hasenknopf B., Li J., Bareyt S., Lacôte E., Thorimbert S., Malacria M., Gouzerh P., Cochet C.
Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase K2
Chem. Biol. 2008,15:683−692.

27.    Prudent R., Moucadel V., López−Ramos M., Aci S., Laudet B., Mouawad L., Barette C., Einhorn J., Einhorn C., Denis J−N., Bisson G., Schmidt F., Roy S., Lafanechère L., Florent J−C., Cochet C.
Expanding the chemical diversity of CK2 inhibitors
Mol. Cell. Biochem.,2008, 316:71−85.

28.    Sève P., Reiman T., Isaac S., Trillet−Lenoir V., Lafanechère L., Sawyer M., Dumontet C. Protein abundance of class III beta−tubulin but not Delta2−alpha−tubulin or tau is related to paclitaxel response in carcinomas of unknown primary site.
Anticancer Res., 2008, 28:1161−1167.

29.    Hoang T.M., Favier B., Valette A., Barette C., Nguyen C-H., Lafanechère L., Grierson D.S., Dimitrov S., Molla A.
Benzo[e]pyridoindoles, novel inhibitors of the aurora kinases
Cell Cycle. 2009, 8:765-772.

30.    Peris L., Wagenbach M., Lafanechère L., Brocard J., Moore A.T., Kozielski F., Job D., Wordeman L. and Andrieux, A.
Motor-dependent microtubule disassembly driven by tubulin tyrosination

J. Cell Biol., 2009, 185: 1159 – 1166

31.    Soleilhac E., Nadon R. and Lafanechère L.,
High-content screening for the discovery of pharmacological compounds: advantages, challenges and potential benefits of recent technological developments
Expert Opin. Drug Discov., 2010, 5: 135-144.

32.    Prudent R., Moucadel V., Nguyen C.H., Barette C., Schmidt F., Florent J.C., Lafanechère L., Sautel C.F., Duchemin-Pelletier E., Spreux E., Filhol O., Reiser J.B., Cochet C.
Antitumor Activity of Pyridocarbazole and Benzopyridoindole Derivatives that Inhibit Protein Kinase CK2.
Cancer Res. 2010, 70: 9865-9874.

33.    Dumontet C, Krajewska M, Treilleux I, Mackey JR, Martin M, Rupin M, Lafanechere L, Reed JC. BCIRG001 Molecular Analysis: Prognostic Factors in Node-Positive Breast Cancer Patients Receiving Adjuvant Chemotherapy.
Clin Cancer Res. 2010,16:3988-3997.

34.    Prudent R., López Ramos M ., Moucadel V., Sautel C., Barette C., Lafanechère L., Mouawad L.,Grierson D., Schmidt F., Florent J-C, Filippakopoulos P., Bullock A.N., Knapp S., Reiser J-B and Cochet C.
New potent dual inhibitors of CK2 and Pim kinases : Discovery and structural insight.
FASEB J., 2010, 24:3171-3185.

35.    Moucadel V, Prudent R, Sautel CF, Teillet F, Barette C, Lafanechere L, Receveur-Brechot V, Cochet C.
Antitumoral activity of allosteric inhibitors of protein kinase CK2.
Oncotarget. 2011, 2:997-1010.

36.    Lo E., Soleilhac E., Martinez A., Lafanechère L. and Nadon R.
Intensity quantile estimation and mapping – a novel algorithm for the correction of image non-uniformity bias in HCS data
Bioinformatics, 2012, 28: 2632-2639

37.    Prudent R., Vassal-Stermann E., Nguyen C-H., Pillet C., Martinez A., Prunier C., Barette C.  Soleilhac E., Filhol O., Beghin A., Valdameri G., Honoré S., Aci-Sèche S. Grierson D., Antonipillai J., Li R., Di Pietro A., Dumontet C., Braguer D., Florent J-C., Knapp S., Bernard O. and Lafanechère L.
Pharmacological inhibition of LIM Kinase stabilizes microtubules and inhibits neoplastic growth
Cancer Res., 2012, 72:4429-4439

38.    Prudent R., Vassal-Stermann E., Nguyen C-H., Mollaret M., Viallet J., Castan A., Martinez A., Barette C., Pillet C., Valdameri G., Soleilhac E., Di Pietro A., Feige J-J., Billaud M., Florent J-C. and Lafanechère L.
Azaindole derivatives are inhibitors of microtubule dynamics, with anticancer and anti-angiogenic activities
British Journal of Pharmacology, 2013, 168:673-685.

39.    Boussouar A., Barette C., Nadon R., Saint-Léger A., Broucqsault N., Ottaviani A., Firozhoussen A., Lu Y., Lafanechère L., Gilson E., Magdinier F., Ye J.
Acacetin and chrysin, two polyphenolic compounds, alleviate telomeric position effect in human cells.
Mol Ther Nucleic Acids. 2013 August;2(8):e116.


40.    Theron A.E., Nolte E.M., Lafanechère L., Joubert A.M.
 Molecular crosstalk between apoptosis and autophagy induced by a novel 2-methoxyestradiol analogue in cervical adenocarcinoma cells
Cancer Cell Int. 2013 August;13(1):87.

41.    Visagie M., Theron A., Mqoco T., Vieira W., Prudent R., Martinez A., Lafanechère L.,  Joubert A.
Sulphamoylated 2-methoxyestradiol analogues induce apoptosis in adenocarcinoma cell lines.
PLoS One. 2013 Sep 5;8(9):e71935

42.    Prudent R., Soleilhac E., Barette C., Fauvarque M-O et Laurence Lafanechère
Les criblages phénotypiques ou comment faire d'une pierre deux coups : Découvrir la cible et la molécule pharmacologique capable de la réguler
Médecine/Sciences, 2013, 29:897-905.

43.    Murie C., Barette C., Lafanechère L., Nadon R.
Single Assay-wide Variance Experimental (SAVE) Design for High-Throughput Screening.
Bioinformatics. 2013 Sep 20.`

44 Murie C., Barette C., Lafanechère L., Nadon R.
Control-Plate Regression (CPR) Normalization for High-Throughput Screens with Many Active Features.
J Biomol Screen. 2013 Dec 18

Livres et ouvrages
1.    Premier livre de chemogénomique en langue française : "Chemogénomique: Des petites molécules pour explorer le vivant", édité par E. Maréchal, S. Roy, L. Lafanechère, 2007,  Grenoble-Science (EDPS).
 ISBN 978 2 75980 005 6

2.    Chemogenomics and Chemical Genetics. User's Introduction for Biologists, Chemists and Informaticians; Eric Maréchal, Sylvaine Roy and Laurence Lafanechère, editors, Springer-Verlag Berlin and Heidelberg GmbH & Co. ,juin 2011, 256 pages.
 ISBN 978 3 64219 614 0

Chapitres d’ouvrages
2007-1 Maréchal, E., Roy S. and  Lafanechère L.
Le processus de criblage pharmacologique : la petite molécule, la cible biologique, l’automate, le signal et l’information
In " Chemogénomique: Des petites molécules pour explorer le vivant ", E. Maréchal, S. Roy and L. Lafanechère, eds, Grenoble-Science (EDPS).

2007-2 Lafanechère L.
Le criblage phénotypique sur cellules et les stratégies de génétique chimique directe
In " Chemogénomique: Des petites molécules pour explorer le vivant", E. Maréchal, S. Roy  and L. Lafanechère, eds, Grenoble-Sciences (EDPS).

2011-1 Maréchal, E., Roy S. and  Lafanechère L.
The pharmacological screening process: the small molecule, the biological screen, the robot, the signal and the information
In "Chemogenomics and Chemical Genetics". Eric Maréchal, Sylvaine Roy and Laurence Lafanechère, editors, Springer-Verlag Berlin and Heidelberg GmbH & Co. , 2011,pp 7-21

2011-2 Lafanechère L.
Phenotypic Screening with Cells and Forward Chemical Genetics Strategies
In Chemogenomics and Chemical Genetics. Eric Maréchal, Sylvaine Roy and Laurence Lafanechère, editors, Springer-Verlag Berlin and Heidelberg GmbH & Co. , 2011, pp 87-102

2011-3 Lafanechère L. and Job D.
Preparation of pure tyrosinated and detyrosinated tubulin isoforms
 In "Microtubule dynamics: methods and protocols", A. Straube, editor, Methods Mol. Biol., Springer, New-York, Dordrecht, Heidelberg, London, ISBN 978 1 61779 252 6. 777: 71-86.

2011-4 Wieczorek S., Aci S., Bisson G., Godon M ; Lafanechère L., Maréchal E. and Roy S.,
Clustering Libraries of Compounds into Families: Asymmetry-Based Similarity Measure to Categorize Small Molecules.
In " Systems and Computational Biology - Bioinformatics and Computational Modeling “,Ning-Sun Yang, ed,  2011, Intech, ISBN 978-953-307-875-5