ChemBioScreen
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annuaire

Soleilhac Emmanuelle

Ingénieur Chercheur CEAMise à jour le 04/01/2017


Equipe

Plateforme

Brevets / Publications / Communications

Brevets 

1.    Fauvarque MO, Mortier M, Pillet C, Aguilar C, Soleilhac E, Barette C,  Remusat V, Terme T, Vanel T. (2016) Brevet d’invention n°EP16306033.8. “Heterocyclic napthtoquinones derivatives for use in the treatment of cancers including Cushing disease”.

2.  Filhol-Cochet O., Cochet C., Giacosa S., Pillet C., Barette C., Soleilhac E. (2015) Brevet Européen N° 15306469.6. « A synthetic lethal drug combination for treating renal cell carcinoma”.

3.  Soleilhac E., Lafanechère L., Martinez A., Barette C. (2013)  Brevet d’invention, n°13 54925. « Composés de type Phényle Propénamide pour leur utilisation en tant que médicament ».

 

Publications

1.      Jacomin A.-C., Bescond A., Soleilhac E., Gallet B., Schoehn G., Fauvarque M.-O., Taillebourg E. (2015) The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila. PLoS ONE 10(11): e0143078. doi:10.1371/journal.pone.0143078.

2.      Martinez A. *, Soleilhac E. *, Barette C., Prudent R., Gozzi G.J., Vassal-Stermann E., Pilet C., Di Pietro A., Fauvarque M.O., Lafanechere L. (2015) Novel synthetic pharmacophores inducing a stabilization of cellular microtubules. Curr Cancer Drug Targets. 15(1):2-13.

3.      Brodin P, DelNery E, Soleilhac E. (2015) [High content screening in chemical biology: overview and main challenges]. Med Sci (Paris). 31(2):187-96.

4.      Barette C., Soleilhac E., Charavay C., Cochet C., Fauvarque M.O. (2015) [Strength and specificity of the CMBA screening platform for bioactive molecules discovery]. Med Sci (Paris). 31(4):423-31.

5.      Prudent R., Soleilhac E., Barette C., Fauvarque M.O., Lafanechère L. (2013) [Phenotypic screens or one stone to kill two birds: discover the target and its pharmacological regulator]. Med Sci (Paris). 29(10):897-905.

6.      Prudent R., Vassal-Stermann É., Nguyen C.-H., Mollaret M., Viallet J., Desroches-Castan A., Martinez A., Barette, C., Pilet C., Valdameri G., Soleilhac E. et al. (2013). Azaindole derivatives are inhibitors of microtubule dynamics, with anti-cancer and anti-angiogenic activities. Br. J. Pharmacol. 168, 673–685.

7.      Prudent R, Vassal-Stermann E, Nguyen CH, Pilet C, Martinez A, Prunier C, Barette C, Soleilhac E, Filhol O, Beghin A, Valdameri G, Honore S, Aci-Seche S, Grierson D, Antonipillai J, Li R, Di Pietro A, Dumontet C, Braguer D, Florent JC, Knapp S, Bernard O and Lafanechere L (2012). Pharmacological inhibition of lim kinase stabilizes microtubules and inhibits neoplastic growth. Cancer Res. 72(17): 4429-4439.

8.      Lo E, Soleilhac E, Martinez A, Lafanechere L and Nadon R (2012). Intensity quantile estimation and mapping - a novel algorithm for the correction of image non-uniformity bias in HCS data. Bioinformatics 28(20): 2632-2639.

9.      Soleilhac E., Nadon R. and Lafanechère L. (2010) High-content screening for the discovery of pharmacological compounds: Advantages, challenges and potential benefits of recent technological developments. Expert Opin. Drug Discov. 5: 2-10.

10.  Fonrose X., Ausseil F., Soleilhac E., Masson V., David B., Pouny I., Cintrat J-C., Rousseau B., Barette C., Massiot G. and Lafanechère L. (2007) Parthenolide inhibits tubulin carboxypeptidase activity. Cancer Res., 67: 3371-8.

11.  Vassal E., Barette C., Fonrose X., Dupont R., Sans-Soleilhac E. and Lafanechère L. (2006) Miniaturization and validation of a sensitive multi-parametric cell-based assay for the concomitant detection of microtubule-destabilizing and microtubule-stabilizing agents. J. Biomol. Screen, 11: 377-389.

12.  Sans-Soleilhac E., Barette C., Wieczorek S., Roy S., Maréchal E. and Lafanechère L. (2003) Criblages phénotypiques et "génétique chimique directe" : une approche innovante pour la découverte de molécules bio-actives et/ou de candidats médicaments. Spectra Analyse, 32: 33-37.

13.  Duperray A. and Sans E. (2002). Interaction des cellules sanguines et des cellules endothéliales. In Biologie et pathologie du coeur et des vaisseaux, Paris: Flammarion médecine-sciences. chap. 31, pp. 345–356.

14.  Sans E., Delachanal E. and Duperray A. (2001). Analysis of the roles of ICAM-1 in neutrophil transmigration using a reconstituted mammalian cell expression model: implication of ICAM-1 cytoplasmic domain and Rho-dependent signaling pathway. J. Immunol. 166, 544–551.